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Eligibility of individuals with subclinical coronary artery calcium and intermediate coronary heart disease risk for reclassification (from the Framingham Heart Study).
- Source :
-
The American journal of cardiology [Am J Cardiol] 2009 Jun 15; Vol. 103 (12), pp. 1710-5. Date of Electronic Publication: 2009 May 03. - Publication Year :
- 2009
-
Abstract
- Coronary artery calcium (CAC) predicts risk for coronary heart disease (CHD) events and perhaps CAC testing may further stratify risk in individuals at intermediate CHD risk. We sought to determine the percentage of participants at intermediate CHD risk who could potentially be reclassified as having a high CHD risk based on the presence of a high CAC score and the prevalence, treatment, and control of CHD risk factors in this group. Framingham Heart Study Offspring and Third Generation cohort participants underwent multidetector computed tomography (n = 3,529, mean age 51 years, 48% women). High CAC was defined as >or=90th age- and gender-specific percentiles based on a healthy reference group or by an absolute modified Agatston score of 100 HU. Prevalence of CHD risk factors (hypertension, hypercholesterolemia, high low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol, smoking, and obesity), their treatment, and control was compared between nondiabetic participants with and without high CAC. Of the 595 participants at intermediate CHD risk, 22% had CAC >or=90th percentile and 39% had CAC >or=100 and could be eligible for reclassification as having a high CHD risk based on the presence of a high CAC score. There were no statistically significant differences in prevalence, treatment, and control of risk factors between those with and without high CAC. In conclusion, prevalence of CHD risk factors did not differ between intermediate-risk participants with and without high CAC. Approximately 25% of intermediate-risk individuals have high CAC scores and may be eligible for reclassification into a higher-risk category.
- Subjects :
- Adult
Calcinosis diagnostic imaging
Calcinosis epidemiology
Coronary Angiography methods
Coronary Disease diagnostic imaging
Coronary Disease epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
Tomography, X-Ray Computed
United States epidemiology
Calcinosis classification
Calcium metabolism
Coronary Disease classification
Coronary Vessels metabolism
Risk Assessment methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1913
- Volume :
- 103
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 19539080
- Full Text :
- https://doi.org/10.1016/j.amjcard.2009.02.020