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Reduced-intensity conditioning allogeneic stem cell transplantation with donor T-cell depletion using alemtuzumab added to the graft ('Campath in the bag').
- Source :
-
Current opinion in oncology [Curr Opin Oncol] 2009 Jun; Vol. 21 Suppl 1, pp. S27-9. - Publication Year :
- 2009
-
Abstract
- Reduced-intensity conditioning (RIC) has allowed the use of allogeneic stem cell transplantation (alloSCT) for haematological malignancies in elderly patients. A major problem of this type of transplantation is the high incidence of persisting chronic graft-versus-host disease (GvHD), leading to increased morbidity and mortality. The inclusion of alemtuzumab added to the graft ('Campath in the bag') for donor T-cell depletion offers an easy procedure to diminish the incidence of GvHD. Good engraftment is observed in most patients, whereas almost no GvHD is observed after transplantation. Most patients become mixed chimeric after transplantation, requiring donor lymphocyte infusion for conversion to full donor chimerism. Although subsequent acute and chronic GvHD is observed in 50-60% of patients, it is responsive to therapy in many patients, resulting in a low incidence of persisting chronic GvHD. AlloSCT with RIC and alemtuzumab-induced T-cell depletion offers a suitable platform for the investigation of novel cellular immunotherapy.
- Subjects :
- Adult
Aged
Alemtuzumab
Antibodies, Monoclonal, Humanized
Antineoplastic Agents administration & dosage
Graft vs Host Disease etiology
Graft vs Host Disease metabolism
Humans
Leukemia metabolism
Leukemia therapy
Lymphocyte Depletion
Middle Aged
T-Lymphocytes metabolism
Transplantation, Homologous
Treatment Outcome
Antibodies, Monoclonal administration & dosage
Antibodies, Neoplasm administration & dosage
Graft vs Host Disease prevention & control
Stem Cell Transplantation adverse effects
T-Lymphocytes drug effects
Transplantation Conditioning methods
Subjects
Details
- Language :
- English
- ISSN :
- 1531-703X
- Volume :
- 21 Suppl 1
- Database :
- MEDLINE
- Journal :
- Current opinion in oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19561408
- Full Text :
- https://doi.org/10.1097/01.cco.0000357472.76337.0e