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Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors.
- Source :
-
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2009 Sep; Vol. 108 (3), pp. 417-24. Date of Electronic Publication: 2009 Jul 01. - Publication Year :
- 2009
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Abstract
- Objective: The aim was to evaluate the expression of matrix metalloproteinases (MMPs) 7 and 26 in ameloblastomas and adenomatoid odontogenic tumors (AOTs).<br />Study Design: Twenty intraosseous solid ameloblastomas and 10 intraosseous AOTs were evaluated regarding immunohistochemical expression of MMP-7 and -26 in the epithelium and stroma.<br />Results: There was no statistically significant difference in MMP-7 and -26 expression between the epithelium of ameloblastomas (P = .50) and AOTs (P = .90). Stromal staining for MMP-7 was evident in all cases. For MMP-26, stromal staining was observed in 65% of ameloblastomas and 50% of AOTs, and this difference was not statistically significant (P = .69).<br />Conclusion: The marked expression of these matrilysins suggests their role in the process of tissue remodeling and growth in the studied tumors, but it does not relate to the their distinct patterns of aggressiveness.
- Subjects :
- Connective Tissue enzymology
Endothelial Cells enzymology
Epithelial Cells enzymology
Epithelium enzymology
Fibroblasts enzymology
Humans
Immunohistochemistry
Ameloblastoma enzymology
Matrix Metalloproteinase 7 analysis
Matrix Metalloproteinases, Secreted analysis
Odontogenic Tumors enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1528-395X
- Volume :
- 108
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
- Publication Type :
- Academic Journal
- Accession number :
- 19570695
- Full Text :
- https://doi.org/10.1016/j.tripleo.2009.03.035