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Is D2-40 a useful marker for distinguishing malignant mesothelioma from pulmonary adenocarcinoma and benign mesothelial proliferations?
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2009; Vol. 205 (11), pp. 749-52. Date of Electronic Publication: 2009 Jul 01. - Publication Year :
- 2009
-
Abstract
- Since pulmonary adenocarcinomas, malignant mesotheliomas (MM), and sometimes benign mesothelial proliferations show a great histomorphological resemblance to each other, an immunohistochemical panel is usually necessary for differential diagnosis. D2-40 is an available monoclonal antibody, which is already in use as a lymphatic endothelial marker. It has also been suggested to be useful in identifying the mesothelial differentiation. The aim of this study is to compare D2-40 immunostaining in MM, pulmonary adenocarcinoma, and benign mesothelial proliferations. In this retrospective study, D2-40 immunostaining was investigated in 37 cases of MM, 36 cases of pulmonary adenocarcinoma, and 31 cases of benign mesothelial proliferation. The diagnosis of MM had previously been confirmed by a panel including calretinin, CK5/6, and CEA. Predominantly membranous immunoreactivity was observed in 51% of MMs and in 55% of benign mesothelial proliferations. All the 36 pulmonary adenocarcinomas were negative. These results were statistically significant (p<0.001). We believe that D2-40 may be helpful in the differential diagnosis of MM from pleural involvement of pulmonary adenocarcinoma.
- Subjects :
- Adenocarcinoma metabolism
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal, Murine-Derived
Biomarkers, Tumor metabolism
Chi-Square Distribution
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Lung Neoplasms metabolism
Male
Mesothelioma metabolism
Middle Aged
Pleura metabolism
Pleural Neoplasms diagnosis
Pleural Neoplasms metabolism
Solitary Fibrous Tumor, Pleural metabolism
Adenocarcinoma diagnosis
Antibodies, Monoclonal metabolism
Lung metabolism
Lung Neoplasms diagnosis
Mesothelioma diagnosis
Solitary Fibrous Tumor, Pleural diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 205
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 19573998
- Full Text :
- https://doi.org/10.1016/j.prp.2009.06.001