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PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Sep 11; Vol. 387 (1), pp. 127-31. Date of Electronic Publication: 2009 Jul 01. - Publication Year :
- 2009
-
Abstract
- Phosphatidylinositol 5-phosphate (PtdIns5P), the most recently discovered phosphoinositide, has been proposed to play a role as a lipid mediator of intracellular signaling. We have previously shown that PtdIns5P generated by IpgD, an effector of the causative agent of dysentery Shigella flexneri, activates the PI 3-kinase/Akt pathway. Here, we demonstrate that PtdIns5P is able to protect Akt from dephosphorylation. This effect is not due to inhibition of the phosphoinositide phosphatase regulating PtdIns(3,4,5)P(3) levels PTEN but rather to PtdIns5P-induced phosphorylation and subsequent inhibition of the catalytic subunit of PP2A phosphatases. These data shed light on a new mechanism used by S. flexneri bacteria to sustain Akt activation to increase survival of the host cells during bacterial replication.
- Subjects :
- HeLa Cells
Humans
PTEN Phosphohydrolase antagonists & inhibitors
Phosphatidylinositol Phosphates pharmacology
Phosphorylation
Protein Phosphatase 2 antagonists & inhibitors
Shigella flexneri metabolism
PTEN Phosphohydrolase metabolism
Phosphatidylinositol Phosphates metabolism
Protein Phosphatase 2 metabolism
Proto-Oncogene Proteins c-akt metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 387
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 19576174
- Full Text :
- https://doi.org/10.1016/j.bbrc.2009.06.139