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Dihydroavenanthramide D protects pancreatic beta-cells from cytokine and streptozotocin toxicity.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Sep 11; Vol. 387 (1), pp. 97-102. Date of Electronic Publication: 2009 Jul 01. - Publication Year :
- 2009
-
Abstract
- Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component of oat. Although its anti-inflammatory, antiatherosclerotic, and antioxidant effects have been reported, the effect of DHAvD on type 1 diabetes is unknown. Therefore, in this study, the effect of DHAvD on cytokine- or streptozotocin-induced beta-cell damage was investigated. Treatment of RINm5F insulinoma cells or isolated islets with IL-1beta and IFN-gamma induced beta-cell damage through a NF-kappaB-dependent signaling pathway. DHAvD-pretreated RINm5F cells or islets showed resistance to cytokine toxicity, namely suppressed nitric oxide (NO) production, reduced the inducible form of NO synthase expression, and decreased beta-cell destruction and the normal insulin secretion capacity. Furthermore, pretreatment with DHAvD blocked the development of type 1 diabetes in streptozotocin-treated mice. Prior injection with DHAvD maintained a normal range of plasma glucose and insulin, and retained immunoreactivity for insulin in the pancreas. These results suggest that DHAvD may be used to preserve functional beta-cell mass.
- Subjects :
- Animals
Avena chemistry
Cell Death drug effects
Cell Line, Tumor
Cytokines toxicity
Insulin-Secreting Cells metabolism
Interferon-gamma antagonists & inhibitors
Interferon-gamma toxicity
Interleukin-1beta antagonists & inhibitors
Interleukin-1beta toxicity
Male
Mice
Mice, Inbred ICR
NF-kappa B metabolism
Streptozocin antagonists & inhibitors
Streptozocin toxicity
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Antioxidants pharmacology
Cytokines antagonists & inhibitors
Cytoprotection
Insulin-Secreting Cells drug effects
ortho-Aminobenzoates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 387
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 19576175
- Full Text :
- https://doi.org/10.1016/j.bbrc.2009.06.133