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Determination of naproxen in human urine by high-performance liquid chromatography with direct electrogenerated chemiluminescence detection.
- Source :
-
Talanta [Talanta] 2009 Aug 15; Vol. 79 (3), pp. 676-80. Date of Electronic Publication: 2009 May 03. - Publication Year :
- 2009
-
Abstract
- A simple and sensitive liquid chromatographic method coupled with electrogenerated chemiluminescence (ECL) was described for the separation and quantification of naproxen in human urine. The method was based on the ECL of naproxen in basic NaNO(3) solution with a dual-electrode system. Factors affected the ECL emission were investigated. Under the optimal conditions, the ECL intensity has a linear relationship with the concentration of naproxen in the range of 4.0 x 10(-8)g mL(-1) to 2.0 x 10(-6)g mL(-1) and the detection limit was 1.6 x 10(-8)g mL(-1) (S/N=3). Application of the method to the analyses of naproxen in human urine proved feasible.
Details
- Language :
- English
- ISSN :
- 1873-3573
- Volume :
- 79
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Talanta
- Publication Type :
- Academic Journal
- Accession number :
- 19576429
- Full Text :
- https://doi.org/10.1016/j.talanta.2009.04.048