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New azaphilones, seco-chaetomugilins A and D, produced by a marine-fish-derived Chaetomium globosum.
- Source :
-
Marine drugs [Mar Drugs] 2009 Jun 16; Vol. 7 (2), pp. 249-57. Date of Electronic Publication: 2009 Jun 16. - Publication Year :
- 2009
-
Abstract
- Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells.
- Subjects :
- Animals
Cell Line, Tumor drug effects
HL-60 Cells drug effects
Humans
KB Cells drug effects
Magnetic Resonance Spectroscopy
Mice
Smegmamorpha microbiology
Benzofurans chemistry
Benzofurans pharmacology
Benzopyrans chemistry
Benzopyrans pharmacology
Chaetomium chemistry
Pigments, Biological chemistry
Pigments, Biological pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 19597583
- Full Text :
- https://doi.org/10.3390/md7020249