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Characterization of a spontaneous drug-resistant mutant of monkey B virus (Macacine herpesvirus 1).
- Source :
-
Archives of virology [Arch Virol] 2009; Vol. 154 (9), pp. 1495-7. Date of Electronic Publication: 2009 Jul 16. - Publication Year :
- 2009
-
Abstract
- Monkey B virus (Macacine herpesvirus 1; BV) is an alpha-herpesvirus of macaques that causes serious infections in humans. A spontaneous mutant resistant to penciclovir (PCV) was isolated. Several genes were sequenced to identify mutations potentially responsible for PCV resistance. A single nucleotide deletion in the thymidine kinase (TK) gene was identified. To confirm its role in PCV resistance, several TK recombinants were constructed. A TK-deletion virus and a recombinant carrying the mutation were both resistant to PCV, while a revertant was PCV-sensitive. These results demonstrate that spontaneous drug-resistant mutants of BV do occur and that the BV TK is responsible for sensitivity to PCV.
- Subjects :
- Acyclovir pharmacology
Animals
Guanine
Herpesvirus 1, Cercopithecine drug effects
Humans
Mutation
Viral Proteins genetics
Acyclovir analogs & derivatives
Drug Resistance, Viral genetics
Herpesvirus 1, Cercopithecine genetics
Reverse Transcriptase Inhibitors pharmacology
Thymidine Kinase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 154
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 19609635
- Full Text :
- https://doi.org/10.1007/s00705-009-0452-3