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The safety and usefulness of low molecular weight heparins and unfractionated heparins in patients with acute stroke.
- Source :
-
Expert opinion on drug safety [Expert Opin Drug Saf] 2009 Sep; Vol. 8 (5), pp. 585-97. - Publication Year :
- 2009
-
Abstract
- Stroke is a common cause for morbidity and mortality, causing substantial economic costs. Because thrombosis plays a key role in the pathogenesis of ischaemic stroke, heparins, platelet inhibitors and anticoagulants have been used in stroke management. There were high hopes that patients might benefit from the use of heparins. Unfortunately, these expectations have not been met. Instead, thrombolytics have been shown to result in an improvement of outcome in a considerable fraction of patients with ischaemic stroke. Yet, in other areas of stroke management, such as the prevention of venous thromboembolism after stroke, heparins have found their niche. In this review, we report on the currently available literature on heparins for the reduction of stroke-related morbidity and mortality, the prevention of recurrent stroke as well as the prevention of venous thromboembolism in both ischaemic and haemorrhagic stroke with respect to their risks, such as the haemorrhagic transformation of ischaemic strokes.
- Subjects :
- Acute Disease
Anticoagulants adverse effects
Brain Ischemia drug therapy
Cerebral Hemorrhage chemically induced
Cerebral Hemorrhage drug therapy
Cerebral Hemorrhage prevention & control
Double-Blind Method
Heparin adverse effects
Heparin, Low-Molecular-Weight adverse effects
Humans
Meta-Analysis as Topic
Multicenter Studies as Topic statistics & numerical data
Pulmonary Embolism etiology
Pulmonary Embolism prevention & control
Randomized Controlled Trials as Topic statistics & numerical data
Recurrence
Risk
Stroke etiology
Thrombophilia complications
Thrombophilia drug therapy
Treatment Outcome
Venous Thromboembolism etiology
Venous Thromboembolism prevention & control
Anticoagulants therapeutic use
Heparin therapeutic use
Heparin, Low-Molecular-Weight therapeutic use
Stroke drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-764X
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Expert opinion on drug safety
- Publication Type :
- Academic Journal
- Accession number :
- 19614560
- Full Text :
- https://doi.org/10.1517/14740330903150157