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Identification of an antiamyloidogenic substance from mulberry leaves.
- Source :
-
Neuroreport [Neuroreport] 2009 Aug 26; Vol. 20 (13), pp. 1214-8. - Publication Year :
- 2009
-
Abstract
- Fibrillar aggregates of amyloid beta-peptides are major constituents of the plaques found in the brains of patients with Alzheimer's disease, and have been implicated in the neurotoxicity of Alzheimer's. We previously reported that the methanol extract of mulberry leaves inhibits the formation of amyloid beta-peptide (1-42)-fibrils in vitro, and protects hippocampal neurons from amyloid beta-peptide (1-42)-induced cell death. In this study, we identified antiamyloidogenic substances, pheophorbide a, kaempferol -3-O-glucoside, and kaempferol -3-O-(6-malonyl) glucoside, from the methanol extract of mulberry leaves. We also compared the antiamyloidogenic activity of pheophorbide a with that of other porphyrin-related compounds.
- Subjects :
- Amyloid beta-Peptides chemistry
Amyloid beta-Peptides metabolism
Chlorophyll chemistry
Chlorophyll isolation & purification
Chromatography
Chromatography, High Pressure Liquid
Glucosides isolation & purification
Humans
Kaempferols isolation & purification
Mass Spectrometry
Methanol chemistry
Monosaccharides isolation & purification
Nuclear Magnetic Resonance, Biomolecular
Peptide Fragments chemistry
Peptide Fragments metabolism
Plant Extracts chemistry
Plant Extracts isolation & purification
Porphyrins chemistry
Protein Multimerization drug effects
Amyloid beta-Peptides antagonists & inhibitors
Chlorophyll analogs & derivatives
Glucosides chemistry
Kaempferols chemistry
Monosaccharides chemistry
Morus chemistry
Peptide Fragments antagonists & inhibitors
Plant Leaves chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1473-558X
- Volume :
- 20
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 19617856
- Full Text :
- https://doi.org/10.1097/WNR.0b013e32832fa645