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sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease.
- Source :
-
Immunogenetics [Immunogenetics] 2009 Aug; Vol. 61 (8), pp. 551-6. Date of Electronic Publication: 2009 Jul 23. - Publication Year :
- 2009
-
Abstract
- Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily, and has been identified as a novel mediator of fatty liver disease (FLD). The aim of our study was to further investigate the relationship between TRAIL and FLD. We found that soluble TRAIL (sTRAIL) concentrations in non-alcoholic FLD (NAFLD) patients were significantly higher than those of controls, and that sTRAIL levels positively correlated with triglyceride concentrations in NAFLD patients. Our results also indicated that the AA/TT genotypes of TRAIL at 1525/1595 engendered a lower risk of FLD attack and a less severe form of steatosis for NAFLD patients in Chinese population. This study provides a means to test for susceptibility to FLD and may assist in the diagnosis of FLD. In addition, we found that 1525G/A and 1595C/T sites were in complete linkage disequilibrium in Chinese population. This might indicate a haplotype with high genetic frequency of TRAIL.
- Subjects :
- Adult
Alleles
Asian People genetics
Base Sequence
Case-Control Studies
China
DNA Primers genetics
Fatty Liver, Alcoholic genetics
Fatty Liver, Alcoholic immunology
Female
Gene Frequency
Genotype
Humans
Immunogenetic Phenomena
Linkage Disequilibrium
Male
Middle Aged
Solubility
Fatty Liver genetics
Fatty Liver immunology
Polymorphism, Single Nucleotide
TNF-Related Apoptosis-Inducing Ligand blood
TNF-Related Apoptosis-Inducing Ligand genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1211
- Volume :
- 61
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 19629467
- Full Text :
- https://doi.org/10.1007/s00251-009-0389-4