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Hepatitis A and E virus infections among children in Mongolia.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2009 Aug; Vol. 81 (2), pp. 248-51. - Publication Year :
- 2009
-
Abstract
- To compare the epidemiologic profiles of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections in children in Mongolia, the prevalence of HAV and HEV infections was studied serologically and molecularly among 520 apparently healthy children 7-12 years of age (mean +/- standard deviation, 8.5 +/- 0.8 years) using serum samples obtained in 2004. Total antibody against HAV (anti-HAV) was detected in 438 children (84.2%), whereas IgG antibody against HEV (anti-HEV IgG) was detected in only three subjects (0.6%). All three subjects with anti-HEV IgG were negative for anti-HEV IgM and HEV RNA. The presence of HAV RNA was tested in all 520 subjects, and one child (9-year-old girl) was found to have detectable HAV RNA (subgenotype IA). In conclusion, HEV infection was uncommon, but subclinical HAV infection was highly prevalent among children in Mongolia.
- Subjects :
- Child
Cross-Sectional Studies
Female
Hepatitis A virus genetics
Hepatitis A virus immunology
Hepatitis A virus isolation & purification
Hepatitis Antibodies blood
Hepatitis E virus genetics
Hepatitis E virus immunology
Hepatitis E virus isolation & purification
Humans
Male
Mongolia epidemiology
Phylogeny
Prevalence
RNA, Viral analysis
Rural Population
Urban Population
Hepatitis A epidemiology
Hepatitis E epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 81
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 19635878