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Effect of age on gingival crevicular fluid concentrations of MIF and PGE2.
- Source :
-
Journal of dental research [J Dent Res] 2009 Jul; Vol. 88 (7), pp. 639-43. - Publication Year :
- 2009
-
Abstract
- We used an experimental gingivitis study design to compare crevicular fluid concentrations of Migration Inhibitory Factor (MIF) and Prostaglandin E(2) (PGE(2)) in younger (18 to 30 yrs) and older (46 to 77 yrs) healthy adults. PGE(2) increased after 1 wk in younger participants, whereas it decreased in older individuals after 1 wk of plaque accumulation. A significant interaction between age and time was observed for PGE(2) (p = 0.04). High concentrations of MIF were identified in both age groups at baseline. MIF increased in the younger participants, whereas in the older individuals a decrease over time was observed. MIF concentration was positively correlated with plaque index and gingival index in the older age group. Total counts of bacteria, Parvimonas micra and Prevotella intermedia, were significantly correlated with MIF concentration in older participants. In conclusion, MIF and PGE(2) production in response to bacterial accumulation seems to be modified by age.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Bacterial Typing Techniques
Dental Plaque microbiology
Dinoprostone analysis
Female
Gingivitis microbiology
Humans
Immunity, Cellular physiology
Macrophage Migration-Inhibitory Factors analysis
Male
Middle Aged
Peptostreptococcus isolation & purification
Polymerase Chain Reaction
Prevotella intermedia isolation & purification
Young Adult
Dinoprostone metabolism
Gingival Crevicular Fluid chemistry
Gingivitis immunology
Gingivitis metabolism
Macrophage Migration-Inhibitory Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1544-0591
- Volume :
- 88
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of dental research
- Publication Type :
- Academic Journal
- Accession number :
- 19641151
- Full Text :
- https://doi.org/10.1177/0022034509340148