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Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells.
- Source :
-
Fertility and sterility [Fertil Steril] 2009 Dec; Vol. 92 (6), pp. 2119-21. Date of Electronic Publication: 2009 Jul 31. - Publication Year :
- 2009
-
Abstract
- Insulin resistance on porcine granulosa cells was induced by wortmannin, the phosphatidylinositol-3-kinase inhibitor, and insulin signaling key molecules were investigated including glut(4) and mitogen-activated protein kinase. Granulosa insulin resistance decreased glut(4) expression but increased mitogen-activated protein kinase, indicating the cross talk between the metabolic and mitogenic pathways of insulin signaling in the ovary.
- Subjects :
- Animals
Cells, Cultured
Female
Gene Expression drug effects
Gene Expression physiology
Glucose Transporter Type 4 genetics
Glucose Transporter Type 4 metabolism
Granulosa Cells cytology
MAP Kinase Signaling System drug effects
MAP Kinase Signaling System physiology
Swine
Wortmannin
Androstadienes pharmacology
Granulosa Cells drug effects
Granulosa Cells metabolism
Insulin Resistance physiology
Phosphodiesterase Inhibitors pharmacology
Phosphoinositide-3 Kinase Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 92
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 19647237
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2009.06.019