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The clinical value of neutrophil extracellular traps.
- Source :
-
Medical microbiology and immunology [Med Microbiol Immunol] 2009 Nov; Vol. 198 (4), pp. 211-9. Date of Electronic Publication: 2009 Aug 04. - Publication Year :
- 2009
-
Abstract
- Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.
Details
- Language :
- English
- ISSN :
- 1432-1831
- Volume :
- 198
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medical microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 19653000
- Full Text :
- https://doi.org/10.1007/s00430-009-0121-x