Back to Search
Start Over
Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin".
- Source :
-
Organic letters [Org Lett] 2009 Sep 03; Vol. 11 (17), pp. 3970-3. - Publication Year :
- 2009
-
Abstract
- Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a delta-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 11
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 19653648
- Full Text :
- https://doi.org/10.1021/ol901553w