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Tissue selectivity in multiple endocrine neoplasia type 1-associated tumorigenesis.

Authors :
Gracanin A
Dreijerink KM
van der Luijt RB
Lips CJ
Höppener JW
Source :
Cancer research [Cancer Res] 2009 Aug 15; Vol. 69 (16), pp. 6371-4. Date of Electronic Publication: 2009 Aug 04.
Publication Year :
2009

Abstract

The phenotype of the multiple endocrine neoplasia type 1 (MEN1) syndrome cannot be explained solely by the expression pattern of the predisposing gene MEN1 and its encoded protein, menin. This review addresses putative factors determining MEN1-associated tissue-selective tumorigenesis. Menin's interaction with mixed-lineage leukemia protein-containing histone methyl transferase (MLL-HMT) complex mediates tissue-selective tumor-suppressing and tumor-promoting effects of menin, and as such could be decisive for the predisposition of individual tissues to MEN1-associated tumorigenesis. In tissues in which menin acts as a tumor suppressor, tumorigenesis could depend on the inability of such tissues to adequately compensate for MEN1 gene loss, whereas the variable clinical presentation of MEN1 in individual patients could be a reflection of additional epigenetic factors and/or modifier genes. Further research on this topic may facilitate development of novel therapeutic strategies that could prevent or delay the onset of MEN1-associated tumorigenesis.

Details

Language :
English
ISSN :
1538-7445
Volume :
69
Issue :
16
Database :
MEDLINE
Journal :
Cancer research
Publication Type :
Academic Journal
Accession number :
19654304
Full Text :
https://doi.org/10.1158/0008-5472.CAN-09-0678