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Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease.

Authors :
Marinho CR
Nuñez-Apaza LN
Bortoluci KR
Bombeiro AL
Bucci DZ
Grisotto MG
Sardinha LR
Jorquera CE
Lira S
Lima MR
Alvarez JM
Source :
Microbes and infection [Microbes Infect] 2009 Nov; Vol. 11 (13), pp. 1037-45. Date of Electronic Publication: 2009 Aug 04.
Publication Year :
2009

Abstract

The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease.

Details

Language :
English
ISSN :
1769-714X
Volume :
11
Issue :
13
Database :
MEDLINE
Journal :
Microbes and infection
Publication Type :
Academic Journal
Accession number :
19660570
Full Text :
https://doi.org/10.1016/j.micinf.2009.07.011