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A comprehensive view on 4-methyl-2-quinazolinamine, a new microbial alkaloid from Streptomyces of TCM plant origin.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2009 Aug; Vol. 62 (8), pp. 439-44. Date of Electronic Publication: 2009 Aug 07. - Publication Year :
- 2009
-
Abstract
- In the course of our chemical and biological screening program for yet unidentified microbial metabolites, we selected plants of Traditional Chinese Medicine (TCM) as habitats for talented Streptomycetes producer strains for the first time. Liquid pure cultures of strain Streptomyces sp. GS DV232 were found to contain 4-methyl-2-quinazolinamine (1), a potent alkaloid yet unknown from nature. In this study, we investigated the chemical and crystal structure of 1, as well as its antiproliferative bioactivity, and addressed the unusual biosynthesis using feeding experiments.
- Subjects :
- Alkaloids biosynthesis
Alkaloids pharmacology
Anti-Bacterial Agents biosynthesis
Anti-Bacterial Agents pharmacology
Antibiotics, Antineoplastic biosynthesis
Antibiotics, Antineoplastic pharmacology
Bacteria drug effects
Candida albicans drug effects
Cell Line, Tumor
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Fermentation
Humans
Mass Spectrometry
Medicine, Chinese Traditional
Molecular Conformation
Plant Leaves microbiology
Quinazolines pharmacology
Alkaloids chemistry
Anti-Bacterial Agents chemistry
Antibiotics, Antineoplastic chemistry
Filipendula microbiology
Quinazolines chemistry
Streptomyces chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 62
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 19662085
- Full Text :
- https://doi.org/10.1038/ja.2009.68