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Pathological and parasitological protection in goats immunised with recombinant cathepsin L1 and challenged with Fasciola hepatica.
- Source :
-
Veterinary journal (London, England : 1997) [Vet J] 2010 Sep; Vol. 185 (3), pp. 351-3. Date of Electronic Publication: 2009 Aug 07. - Publication Year :
- 2010
-
Abstract
- Fluke burdens, faecal egg output and hepatic damage were assessed in goats immunised with recombinant cathepsin L1 (rCL1) plus Quil A (n=7) or Quil A alone (control; n=7) and challenged with Fasciola hepatica. There were no significant differences in fluke burdens (56+/-26 vs. 92+/-53), average fluke length (20.9+/-3.0 vs. 21.0+/-3.4mm) or faecal egg output (525+/-533 vs. 758+/-677.8 eggs per gram at 17 weeks post-infection) between vaccinated and infected control groups, respectively, but high individual variability was evident. Morphometric and histopathological studies showed reduced hepatic damage in the vaccinated group compared to the infected control, but high individual variability was also recorded. Further vaccine trials in goats should be carried out using a larger number of animals to evaluate rCL1 as a vaccine for fasciolosis in goats.<br /> (Copyright 2009 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adjuvants, Immunologic
Animals
Fascioliasis immunology
Fascioliasis pathology
Fascioliasis prevention & control
Feces parasitology
Female
Goat Diseases immunology
Goat Diseases parasitology
Goat Diseases pathology
Goats
Immunization methods
Liver parasitology
Liver pathology
Parasite Egg Count veterinary
Quillaja Saponins
Recombinant Proteins immunology
Saponins immunology
Cathepsins immunology
Fasciola hepatica immunology
Fascioliasis veterinary
Goat Diseases prevention & control
Immunization veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2971
- Volume :
- 185
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary journal (London, England : 1997)
- Publication Type :
- Academic Journal
- Accession number :
- 19665401
- Full Text :
- https://doi.org/10.1016/j.tvjl.2009.07.004