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Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation.
- Source :
-
Nature neuroscience [Nat Neurosci] 2009 Sep; Vol. 12 (9), pp. 1145-51. Date of Electronic Publication: 2009 Aug 09. - Publication Year :
- 2009
-
Abstract
- Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penicillinase as a control. They were assigned to two alternative rehabilitation procedures, the first reinforcing skilled reaching and the second reinforcing general locomotion. Chondroitinase treatment enhanced sprouting of corticospinal axons independently of the rehabilitation regime. Only the rats receiving the combination of chondroitinase and specific rehabilitation showed improved manual dexterity. Rats that received general locomotor rehabilitation were better at ladder walking, but had worse skilled-reaching abilities than rats that received no treatment. Our results indicate that chondroitinase treatment opens a window during which rehabilitation can promote recovery. However, only the trained skills are improved and other functions may be negatively affected.
- Subjects :
- Animals
Axons drug effects
Axons physiology
Cervical Vertebrae
Forelimb
Locomotion drug effects
Locomotion physiology
Male
Motor Skills drug effects
Motor Skills physiology
Nerve Regeneration drug effects
Nerve Regeneration physiology
Pyramidal Tracts drug effects
Pyramidal Tracts injuries
Pyramidal Tracts physiopathology
Rats
Recovery of Function drug effects
Recovery of Function physiology
Chondroitin ABC Lyase therapeutic use
Musculoskeletal Manipulations methods
Neuroprotective Agents therapeutic use
Spinal Cord Injuries drug therapy
Spinal Cord Injuries rehabilitation
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1726
- Volume :
- 12
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 19668200
- Full Text :
- https://doi.org/10.1038/nn.2377