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Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma.
- Source :
-
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2009 Sep; Vol. 68 (9), pp. 972-6. - Publication Year :
- 2009
-
Abstract
- Forkhead box P1 (FOXP1) protein is a transcription factor involved in cell signaling and regulation of gene expression. The overexpression of FOXP1 in a subgroup of systemic diffuse large B-cell lymphomas has been associated with an exceptionally poor clinical outcome. Data on FOXP1 expression in primary central nervous system lymphomas (PCNSL), that is, diffuse large B-cell lymphomas confined to the central nervous system, are not yet available. We analyzed 43 PCNSL from immunocompetent patients. Immunohistochemistry showed expression of FOXP1 protein in 21 (88%) of 24 cases. All 19 PCNSL analyzed by quantitative gene expression analysis showed overexpression of truncated FOXP1 Isoforms 3 and 9 and downregulation of normal-size FOXP1 compared with nonmalignant germinal center B cells, the normal counterpart of PCNSL tumor cells. Thus, truncated FOXP1 isoforms are preferentially overexpressed in PCNSL as they are in diffuse large B-cell lymphomas. Although the mechanisms are presently unclear, this overexpression may contribute to a poor prognosis in PCNSL.
- Subjects :
- Aged
Blotting, Western
Central Nervous System Neoplasms metabolism
Female
Forkhead Transcription Factors biosynthesis
Gene Expression Profiling
Humans
Immunohistochemistry
Lymphoma, Large B-Cell, Diffuse metabolism
Male
Middle Aged
Protein Isoforms
Repressor Proteins biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Central Nervous System Neoplasms genetics
Forkhead Transcription Factors genetics
Gene Expression Regulation, Neoplastic
Lymphoma, Large B-Cell, Diffuse genetics
Repressor Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3069
- Volume :
- 68
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of neuropathology and experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 19680146
- Full Text :
- https://doi.org/10.1097/NEN.0b013e3181b31cd6