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[18F]FLT-PET and [18F]FDG-PET in the evaluation of radiotherapy for laryngeal cancer.
- Source :
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Oral oncology [Oral Oncol] 2009 Dec; Vol. 45 (12), pp. e211-5. Date of Electronic Publication: 2009 Aug 18. - Publication Year :
- 2009
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Abstract
- The evaluation of response to radiotherapy in patients with laryngeal cancer is a challenge because of the difficulty to differentiate between post-therapy changes and recurrent or residual tumor. Positron emission tomography is a non-invasive imaging tool that may be helpful in this differentiation. In this study, [(18)F]-fluoro-3'-deoxy-L-thymidine ([(18)F]FLT), a proliferation tracer is compared with 2-[(18)F]-fluoro-2-deoxy-D-glucose ([(18)F]FDG). Patients with primary laryngeal cancer, scheduled to undergo radiotherapy were included in this study. Patients underwent both [(18)F]FLT-PET and [(18)F]FDG-PET shortly before radiotherapy. Ten patients underwent [(18)F]FLT-PET and [(18)F]FDG-PET 2-3 months after radiotherapy. Scans were analyzed visually for areas of increased tracer uptake. The standardized uptake value (SUV) was measured as a semi-quantitative value of tracer uptake. Fourteen patients, all male, were included in this study. Both [(18)F]FLT-PET and [(18)F]FDG-PET showed increased tracer uptake in 12 out of 14 patients (86%). [(18)F]FDG uptake was significantly higher than [(18)F]FLT uptake (SUV(max): 4.5 vs. 2.4 (P=0.002); SUV(mean): 3.4 vs. 1.9 (P=0.002)). After radiotherapy, 3 patients had histologically proven residual or recurrent laryngeal cancer. [(18)F]FDG was true positive in 2 out of 3 patients, whereas [(18)F]FLT showed increased tracer uptake in only one. Of the remaining 7 patients, [(18)F]FLT was true negative in all, whereas [(18)F]FDG showed increased uptake in one (false positive). [(18)F]FLT-PET is feasible in visualizing laryngeal cancer and its evaluation of treatment. The overall uptake of this tracer is significantly lower as compared with [(18)F]FDG, but tumor to background ratios are comparable.
- Subjects :
- Aged
Aged, 80 and over
Feasibility Studies
Humans
Laryngeal Neoplasms radiotherapy
Male
Middle Aged
Prognosis
Prospective Studies
Sensitivity and Specificity
Dideoxynucleosides pharmacokinetics
Fluorodeoxyglucose F18 pharmacokinetics
Laryngeal Neoplasms diagnostic imaging
Neoplasm Recurrence, Local diagnostic imaging
Positron-Emission Tomography methods
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0593
- Volume :
- 45
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Oral oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19692292
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2009.07.008