Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media.

Authors :: Pérez-Picaso L
Escalante J
Olivo HF
Rios MY
Source :: Molecules (Basel, Switzerland) [Molecules] 2009 Jul 31; Vol. 14 (8), pp. 2836-49. Date of Electronic Publication: 2009 Jul 31.
Publication Year :: 2009
Abstract: Aqueous in situ one-pot N-Boc-deprotection-cyclization of N alpha-Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.

Subjects :: Esters chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Peptides, Cyclic chemistry
Diketopiperazines chemical synthesis
Diketopiperazines chemistry
Microwaves

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