The myasthenic syndrome: anaesthesia in a patient treated with 3.4 diaminopyridine.

Authors :: Telford RJ
Hollway TE
Source :: British journal of anaesthesia [Br J Anaesth] 1990 Mar; Vol. 64 (3), pp. 363-6.
Publication Year :: 1990
Abstract: A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diaminopyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an anticholinesterase, while oral 3.4 diaminopyridine improved neuromuscular transmission further. A combination of anticholinesterase with aminopyridine may be the antagonistic combination of choice in this condition.

Subjects :: 4-Aminopyridine pharmacology
4-Aminopyridine therapeutic use
Aged
Amifampridine
Glycopyrrolate pharmacology
Humans
Male
Neostigmine pharmacology
Vecuronium Bromide antagonists & inhibitors
Vecuronium Bromide pharmacology
4-Aminopyridine analogs & derivatives
Anesthesia, General
Lambert-Eaton Myasthenic Syndrome drug therapy
Potassium Channels drug effects

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