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Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.
- Source :
-
The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] 2009 Jul; Vol. 118 (7), pp. 536-41. - Publication Year :
- 2009
-
Abstract
- Objectives: Prostaglandin (PG) E2 is a potential anti-inflammatory mediator that attenuates airway inflammation. To elucidate the functions of the PGE2 receptors (EP1, EP2, EP3, and EP4) in allergic inflammation, we examined the in vivo effects of EP agonists on mucus hypersecretion and eosinophil infiltration in rat nasal epithelium.<br />Methods: We induced hypertrophic and metaplastic changes in goblet cells in nasal epithelium of ovalbumin-sensitized rats by intranasal challenge with ovalbumin. The effects of subcutaneous injections of EP agonists on mucus production and eosinophil infiltration were examined.<br />Results: The EP4 agonist (1 to 100 microg/kg) dose-dependently inhibited ovalbumin-induced mucus production. The EP2 and EP3 agonists (100 microg/kg) also significantly inhibited mucus production. The EP3 agonist inhibited antigen-induced eosinophil infiltration, whereas the EP1 agonist showed no effect. This suppression of mucus production by the EP4 agonist was only effective when the EP4 agonist was given in the effector phase; administration in the induction phase resulted in no effect.<br />Conclusions: These results indicate that PGE2 acts as an anti-inflammatory mediator via the EP receptors of airways in allergic inflammation. Selective EP agonists may provide a new therapeutic strategy for airway mucus hypersecretion.
- Subjects :
- Alprostadil analogs & derivatives
Alprostadil pharmacology
Animals
Dinoprostone analogs & derivatives
Dinoprostone pharmacology
Disease Models, Animal
Hypertrophy etiology
Male
Metaplasia etiology
Methyl Ethers pharmacology
Nasal Mucosa pathology
Neutrophil Infiltration drug effects
Rats
Rats, Inbred F344
Receptors, Prostaglandin E physiology
Rhinitis pathology
Mucus metabolism
Nasal Mucosa drug effects
Nasal Mucosa metabolism
Receptors, Prostaglandin E agonists
Rhinitis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4894
- Volume :
- 118
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Annals of otology, rhinology, and laryngology
- Publication Type :
- Academic Journal
- Accession number :
- 19708495
- Full Text :
- https://doi.org/10.1177/000348940911800714