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Effects of calcium supplementation on uteroplacental and fetoplacental blood flow in low-calcium-intake mothers: a randomized controlled trial.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2010 Jan; Vol. 202 (1), pp. 45.e1-9. Date of Electronic Publication: 2009 Aug 28. - Publication Year :
- 2010
-
Abstract
- Objective: We postulated that calcium supplementation of calcium-deficient pregnant women would lower vascular resistance in uteroplacental and fetoplacental circulations.<br />Study Design: Pulsatility index (PI) and resistance index (RI) (uterine and umbilical arteries) and presence of bilateral uterine artery diastolic notching were assessed by Doppler ultrasound between 20-36 weeks' gestation in 510 healthy, nulliparous Argentinean women with deficient calcium intake in a randomized, placebo-controlled, double-blinded trial.<br />Results: Average umbilical and uterine artery RI and PI tended to be lower in the supplemented group at each study week. Differences became statistically significant for umbilical artery RI and PI from 32 and 36 weeks, respectively. Estimated probabilities of bilateral uterine artery diastolic notching trended toward lower values in calcium-supplemented women.<br />Conclusion: Calcium supplementation of pregnant women with deficient calcium intake may affect uteroplacental and fetoplacental blood flow by preserving the vasodilation of normal gestation.<br /> (2010 Mosby, Inc.)
- Subjects :
- Adolescent
Adult
Female
Humans
Laser-Doppler Flowmetry
Placenta diagnostic imaging
Pregnancy
Regional Blood Flow drug effects
Ultrasonography, Doppler
Ultrasonography, Prenatal
Uterus diagnostic imaging
Vascular Resistance physiology
Vasodilation drug effects
Vasodilation radiation effects
Young Adult
Calcium, Dietary administration & dosage
Dietary Supplements
Fetus physiology
Placenta blood supply
Uterus blood supply
Vascular Resistance drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 202
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 19716540
- Full Text :
- https://doi.org/10.1016/j.ajog.2009.07.037