Hypertrophic pachymeningitis with MPO-ANCA-positive vasculitis.

Authors :: Horino T
Takao T
Taniguchi Y
Terada Y
Source :: Clinical rheumatology [Clin Rheumatol] 2010 Jan; Vol. 29 (1), pp. 111-3. Date of Electronic Publication: 2009 Sep 02.
Publication Year :: 2010
Abstract: A 75-year-old man presented with headache, right facial palsy, and left hemiparesis. Because of elevated myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) titers and findings from magnetic resonance imaging (MRI) which were compatible with hypertrophic pachymeningitis (HP), he was diagnosed with MPO-ANCA-positive HP. He was treated with the combination therapy of steroid and cyclophosphamide (CY), leading to good prognosis. We present a case of HP associated with MPO-ANCA-positive vasculitis and emphasize the importance of MPO-ANCA tests as a predictable factor for relapse of the disease in order to start earlier treatment for the disease.