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Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.

Authors :
Bonnet M
Ferrier P
Spicuglia S
Source :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2009; Vol. 650, pp. 116-32.
Publication Year :
2009

Abstract

The V(D)J recombination machinery assembles antigen receptor genes from germline V, D and J segments duringlymphocyte development. In alphabetaT cells, this leads to the production of the T-cell receptor (TCR) alpha and beta chains. Notably, V(D)J recombination at the Tcrb locus is tightly controlled at various levels, including cell-type and stage specificities, intralocus ordering and allelic exclusion. Although many of these controls are partly mediated at the level of genomic accessibility to the V(D)J recombinase, recent studies have uncovered novel mechanisms that are also likely to contribute to the developmental regulation of Tcrb gene rearrangement events. In this chapter, we summarize our current knowledge and highlight unanswered questions regarding the regulation of V(D)J recombination at the Tcrb locus, placing emphasis on mouse transgenesis and gene-targeting approaches.

Details

Language :
English
ISSN :
0065-2598
Volume :
650
Database :
MEDLINE
Journal :
Advances in experimental medicine and biology
Publication Type :
Academic Journal
Accession number :
19731806
Full Text :
https://doi.org/10.1007/978-1-4419-0296-2_10