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Sevelamer reduces the efficacy of many other drugs.
- Source :
-
Prescrire international [Prescrire Int] 2009 Aug; Vol. 18 (102), pp. 164-5. - Publication Year :
- 2009
-
Abstract
- (1) Sevelamer, a phosphate-binding polymer, is used to treat hyperphosphataemia in patients with chronic renal failure. Pharmacokinetic studies and some clinical reports have shown that sevelamer binds many drugs, including furosemide, ciclosporin and tacrolimus, thus making them less effective; (2) It is best to take sevelamer some time before or after other drugs.
- Subjects :
- Anuria chemically induced
Chelating Agents administration & dosage
Chelating Agents adverse effects
Chelating Agents pharmacokinetics
Chelating Agents therapeutic use
Cholesterol metabolism
Furosemide antagonists & inhibitors
Humans
Hyperphosphatemia drug therapy
Kidney Failure, Chronic drug therapy
Omeprazole
Polyamines administration & dosage
Polyamines pharmacokinetics
Polyamines therapeutic use
Renal Dialysis adverse effects
Sevelamer
Vitamins antagonists & inhibitors
Drug Interactions
Polyamines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1167-7422
- Volume :
- 18
- Issue :
- 102
- Database :
- MEDLINE
- Journal :
- Prescrire international
- Publication Type :
- Academic Journal
- Accession number :
- 19743578