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Zolpidem increases bladder capacity and decreases urine excretion in rats.
- Source :
-
Neurourology and urodynamics [Neurourol Urodyn] 2010 Apr; Vol. 29 (4), pp. 587-91. - Publication Year :
- 2010
-
Abstract
- Aims: To clarify the effects of zolpidem, a gamma-aminobutyric acid (GABA)(A) receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.<br />Methods: CI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABA(A) receptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water-loaded and Brattleboro rats (genetically vasopressin-deficient). Blood samples were collected from water-loaded rats to determine the aldosterone level 1 and 6 hr after zolpidem administration.<br />Results: Zolpidem increased bladder capacity dose-dependently, but had no significant effect on bladder contraction pressure in CI rats. Bicuculline dose-dependently inhibited zolpidem-induced increases in bladder capacity without affecting bladder contraction pressure. Zolpidem dose-dependently decreased the volume of urine excreted in water-loaded and Brattleboro rats. Compared with the control group, zolpidem significantly increased the aldosterone concentration in the plasma of water-loaded rats 1 hr after administration.<br />Conclusions: Zolpidem increased bladder capacity via a GABAergic mechanism in CI rats, and suppressed urine excretion via a pathway that was not through activation of vasopressin V(2) receptors in water-loaded and Brattleboro rats. These results suggest that zolpidem may improve nocturia via an increase in bladder capacity and a decrease in urine excretion.<br /> ((c) 2009 Wiley-Liss, Inc.)
- Subjects :
- Aldosterone blood
Animals
Bicuculline pharmacology
Cerebral Infarction complications
Cerebral Infarction physiopathology
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
GABA Agonists administration & dosage
GABA Antagonists pharmacology
Infarction, Middle Cerebral Artery complications
Injections, Intravenous
Pyridines administration & dosage
Rats
Rats, Brattleboro
Rats, Sprague-Dawley
Rats, Wistar
Time Factors
Urinary Bladder physiopathology
Urinary Bladder, Overactive etiology
Urinary Bladder, Overactive physiopathology
Urodynamics
Zolpidem
GABA Agonists pharmacology
Pyridines pharmacology
Urinary Bladder drug effects
Urinary Bladder, Overactive drug therapy
Urination drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6777
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurourology and urodynamics
- Publication Type :
- Academic Journal
- Accession number :
- 19760758
- Full Text :
- https://doi.org/10.1002/nau.20797