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Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface.

Authors :
Honda T
Horie M
Daito T
Ikuta K
Tomonaga K
Source :
Journal of virology [J Virol] 2009 Dec; Vol. 83 (23), pp. 12622-5. Date of Electronic Publication: 2009 Sep 23.
Publication Year :
2009

Abstract

Borna disease virus (BDV) is characterized by highly neurotropic infection. BDV enters its target cells using virus surface glycoprotein (G), but the cellular molecules mediating this process remain to be elucidated. We demonstrate here that the N-terminal product of G, GP1, interacts with the 78-kDa chaperone protein BiP. BiP was found at the surface of BDV-permissive cells, and anti-BiP antibody reduced BDV infection as well as GP1 binding to the cell surface. We also reveal that BiP localizes at the synapse of neurons. These results indicate that BiP may participate in the cell surface association of BDV.

Details

Language :
English
ISSN :
1098-5514
Volume :
83
Issue :
23
Database :
MEDLINE
Journal :
Journal of virology
Publication Type :
Academic Journal
Accession number :
19776128
Full Text :
https://doi.org/10.1128/JVI.01201-09