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Gold-catalyzed one-pot cascade construction of highly functionalized pyrrolo[1,2-a]quinolin-1(2H)-ones.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2009 Oct 02; Vol. 74 (19), pp. 7344-8. - Publication Year :
- 2009
-
Abstract
- An efficient protocol was developed for the synthesis of fused heterocyclic multiring compounds pyrrolo[1,2-a]quinolin-1(2H)-ones via a AuBr(3)/AgSbF(6)-catalyzed cascade transformation. Significantly, the strategy affords a straightforward and efficient approach to construction of tricyclic lactam molecular architectures in which two new C-C bonds and one new C-N bond are formed in a one-pot synthetic operation from simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields and with excellent regio- and chemoselectivities.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 74
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19778077
- Full Text :
- https://doi.org/10.1021/jo901418m