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Prevention of amyloidosis in familial Mediterranean fever with colchicine: a case-control study in Armenia.
- Source :
-
Medical principles and practice : international journal of the Kuwait University, Health Science Centre [Med Princ Pract] 2009; Vol. 18 (6), pp. 441-6. Date of Electronic Publication: 2009 Sep 30. - Publication Year :
- 2009
-
Abstract
- Objective: To determine whether or not the use of colchicine decreases the risk of amyloidosis among Armenian patients with familial Mediterranean fever (FMF).<br />Subjects and Methods: The study included 99 Armenian patients from the Center of Medical Genetics database with genetically ascertained FMF; 33 had renal amyloidosis and 66 were randomly selected control patients without renal amyloidosis. Self- reported colchicine use was assessed by interviewer-based questionnaire.<br />Results: The patients with incident amyloidosis were more likely to be older men, but younger at the time of disease onset, and more likely to have had a family history of amyloidosis and M694F mutation in the MEFV gene compared to patients without amyloidosis. The risk of amyloidosis decreased with adequate colchicine use rather than nonadequate use (adjusted odds ratio, OR, 0.48, 95% confidence interval, CI, 0.16-1.43), continuous colchicine use rather than interrupted use (adjusted OR 0.15, 95% CI 0.04-0.53), earlier rather than later initiation age of colchicine treatment (adjusted OR 0.95, 95% CI 0.90-1.01), current colchicine rather than ever/never colchicine use (adjusted OR 0.20, 95% CI 0.05-0.89).<br />Conclusion: The study demonstrated that colchicine treatment is effective in preventing amyloidosis among Armenian patients with FMF and that earlier initiation and continuous therapy at an adequate dose of 1.2-1.8 mg/day may be associated with a decreased amyloidosis risk among Armenian patients with FMF.<br /> (Copyright 2009 S. Karger AG, Basel.)
- Subjects :
- Adult
Age Factors
Amyloidosis etiology
Armenia
Case-Control Studies
Cytoskeletal Proteins genetics
Dose-Response Relationship, Drug
Drug Administration Schedule
Familial Mediterranean Fever complications
Familial Mediterranean Fever genetics
Female
Humans
Male
Middle Aged
Mutation
Odds Ratio
Pyrin
Young Adult
Amyloidosis prevention & control
Colchicine administration & dosage
Familial Mediterranean Fever drug therapy
Tubulin Modulators administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0151
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Medical principles and practice : international journal of the Kuwait University, Health Science Centre
- Publication Type :
- Academic Journal
- Accession number :
- 19797919
- Full Text :
- https://doi.org/10.1159/000235892