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Prognostic stratification in patients who received hormonal therapy for prostate-specific antigen recurrence after radical prostatectomy.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2010 Feb; Vol. 40 (2), pp. 177-80. Date of Electronic Publication: 2009 Oct 16. - Publication Year :
- 2010
-
Abstract
- The present study was undertaken to investigate the predictors in patients who received hormonal therapy (HT) for prostate-specific antigen recurrence (PSAR) after surgery. Predictors for the progression-free survival were assessed in 55 patients who received HT for PSAR after surgery. In multivariate analysis, primary Gleason grade > or =4 and PSA doubling time (PSA-DT) <6 months were independent predictors. The patients were stratified into low-risk group (Gleason grade <4 and PSA-DT > or =6), high-risk group (Gleason grade > or =4 and PSA-DT <6) and intermediate-risk group (all others). In the intermediate- and high-risk groups, progression-free survival rate was significantly higher in patients with PSA level <2 than in those with PSA level > or =2 at the initiation of HT. Primary Gleason grade > or =4 and PSA-DT <6 months are independent predictors. Patients in the intermediate- and high-risk groups may benefit from early HT for PSAR after surgery.
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19837688
- Full Text :
- https://doi.org/10.1093/jjco/hyp133