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Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure.

Authors :
Schuttelaar ML
Kerkhof M
Jonkman MF
Koppelman GH
Brunekreef B
de Jongste JC
Wijga A
McLean WH
Postma DS
Source :
Allergy [Allergy] 2009 Dec; Vol. 64 (12), pp. 1758-65. Date of Electronic Publication: 2009 Oct 14.
Publication Year :
2009

Abstract

Background: Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear.<br />Methods: FLG mutations R501X, 2282del4 and R2447X were genotyped in the Prevention and Incidence of Asthma and Mite Allergy birth cohort (n = 934) to evaluate longitudinally, for up to 8 years, their association with eczema, sensitization, asthma, hay fever and their interaction with cat exposure.<br />Results: The combined FLG mutations were significantly associated with eczema at all ages when occurring in the first year of life (OR = 2.0; 95% CI: 1.4-2.8). Combined FLG mutations were associated with both atopic and nonatopic eczema, as well as asthma (OR = 3.7; 95% CI: 1.8-7.5). When the FLG 2282del4 mutation was analysed separately, it was significantly associated with the development of eczema during the first year, having eczema up to 8 years and sensitization at the age of 8 years, which was enhanced by early-life cat exposure (ORs being 8.2; 95% CI: 2.6-25.9, 6.0; 95% CI: 3.2-11.3 and 5.4; 95% CI: 1.2-23.6 respectively). FLG 2282del4 was significantly associated with hay fever from the age 5 years onwards (OR = 3.9; 95% CI: 1.5-10.5).<br />Conclusions: FLG mutations are associated both with atopic and nonatopic eczema starting in the first year of life. FLG mutations combined with eczema in the first year of life are associated with a later development of asthma and hay fever, a clear example of the atopic march. We confirm that cat exposure enhances the effect of a FLG mutation on the development of eczema and sensitization.

Details

Language :
English
ISSN :
1398-9995
Volume :
64
Issue :
12
Database :
MEDLINE
Journal :
Allergy
Publication Type :
Academic Journal
Accession number :
19839980
Full Text :
https://doi.org/10.1111/j.1398-9995.2009.02080.x