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Methylene blue dye, an accurate dye for sentinel lymph node identification in early breast cancer.
- Source :
-
Anticancer research [Anticancer Res] 2009 Oct; Vol. 29 (10), pp. 4119-25. - Publication Year :
- 2009
-
Abstract
- Purpose: The aim of this prospective study was to analyze the safety of methylene blue dye (MBD) and compare its efficacy with that of isotopic mapping for sentinel lymph node (SLN) identification in breast cancer.<br />Patients and Methods: The SLN procedure, involving isotopic mapping and MBD (subareolar intraparenchymal injections of 2 mL, 10 mg/mL), was performed on 100 patients with early breast cancer.<br />Results: The procedure was safe with a success rate of 99%; SLNs were, respectively, found in 65% by MBD, in 73% by lymphoscintigraphy and in 94% by gamma-probe. Out of 40 metastatic SLNs, 37 were "hot" and 32 stained. Digital examination allowed the detection of 2 additional metastatic LNs.<br />Conclusion: MBD is safe and combination mapping associated with digital examination is the superior method. Modification of the procedure, favouring injections of dilute MBD (4 mL, 1.25 mg/mL) increases MBD efficiency (90%) and maintains low rates of complications.
- Subjects :
- Breast Neoplasms diagnostic imaging
Breast Neoplasms pathology
Breast Neoplasms surgery
Carcinoma in Situ diagnosis
Carcinoma in Situ diagnostic imaging
Carcinoma in Situ pathology
Carcinoma in Situ surgery
Carcinoma, Ductal, Breast diagnosis
Carcinoma, Ductal, Breast diagnostic imaging
Carcinoma, Ductal, Breast pathology
Carcinoma, Ductal, Breast surgery
Female
Humans
Lymph Nodes diagnostic imaging
Middle Aged
Prospective Studies
Radionuclide Imaging
Radiopharmaceuticals
Sulfur
Technetium Tc 99m Sulfur Colloid
Breast Neoplasms diagnosis
Lymph Nodes pathology
Methylene Blue
Sentinel Lymph Node Biopsy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 29
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 19846959