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Spontaneous fusion between the vesicles formed by A2n(B2)n type comb-like block copolymers with a semiflexible hydrophobic backbone.
- Source :
-
The journal of physical chemistry. B [J Phys Chem B] 2009 Nov 19; Vol. 113 (46), pp. 15256-62. - Publication Year :
- 2009
-
Abstract
- The spontaneous vesicle formation and fusion of A(2n)(B(2))(n) (n = 2-10) type comb-like block copolymers with semiflexible hydrophobic backbone are studied via dissipative particle dynamics (DPD) simulations. By systemically varying the solvent condition, we construct a phase diagram to indicate the thermodynamically stable region for vesicles. The spontaneous fusion between the vesicles is studied, whose mechanism is as follows: first, a stalk is formed between the vesicles; then, the holes appear in both vesicles near the feet of the stalk; finally, the stalk bends to circle the holes and the fusion process is completed. This fusion pathway is similar to that observed in Monte Carlo simulations and dynamic self-consistent filed theory but different from those reported in coarse-grained molecular dynamics and DPD simulations. The main reason for the difference may be attributed to the molecular structures used in different simulation techniques.
Details
- Language :
- English
- ISSN :
- 1520-5207
- Volume :
- 113
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- The journal of physical chemistry. B
- Publication Type :
- Academic Journal
- Accession number :
- 19856945
- Full Text :
- https://doi.org/10.1021/jp903570w