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Is there a difference between patients with peak oxygen consumption below 10 ml/kg/min versus between 10 and 14 ml/kg/min? Does the "Grey Zone" really exist?
- Source :
-
Transplantation proceedings [Transplant Proc] 2009 Oct; Vol. 41 (8), pp. 3190-3. - Publication Year :
- 2009
-
Abstract
- Background: Cardiopulmonary exercise testing is an important component of evaluation when orthotopic heart transplantation (OHT) is considered for chronic heart failure (CHF) patients. However there is a question about the accuracy of interpretations of peak oxygen consumption (VO(2)max) used at present.<br />Materials and Methods: We analyzed 302 CHF patients stratified into 3 groups according to VO(2)max (mL/kg/min): group 1 = <10 (n = 37); group 2 = 10-14 (n = 121) and group 3 = >14 (n = 144). We compared the mortality rate, the OHT rate, time to OHT, time to death and pulmonary function tests (PFT) among the groups using ANOVA Kruskal-Wallis tests for analysis in Statistica 7.1.<br />Results: No important differences were observed between groups 1 and 2 (P > .05), but first in comparison with group 3 (P < .05) in terms of mortality (48.6% vs 33.1% vs 21.5%), number of OHT (24.3% vs 32.2% vs 14.6%), time to death (15.4 vs 16.6 vs 34.4 months) or PFT results (forced expiratory volume in the first second forced vital capacity and peak expiratory flow, all as direct or as percent of normal values). In contrast, time to OHT (4.6 vs 6.9 vs 10.9 months) and percent of normal vital capacity (72% vs 81% vs 91%) differed significantly among all groups (P < .05).<br />Conclusion: Patients with VO(2)max between 10 and 14 or <10 mL/kg/min are at similar risk of death.
- Subjects :
- Blood Pressure
C-Reactive Protein metabolism
Creatinine blood
Exercise
Heart Failure physiopathology
Heart Rate
Heart Ventricles physiopathology
Humans
Middle Aged
Respiratory Rate physiology
Uric Acid blood
Vascular Resistance
Ventricular Function, Left physiology
Ventricular Function, Right physiology
Heart Failure surgery
Heart Transplantation physiology
Oxygen Consumption physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 41
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 19857707
- Full Text :
- https://doi.org/10.1016/j.transproceed.2009.07.070