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The Viracept-EMS case: impact and outlook.
- Source :
-
Toxicology letters [Toxicol Lett] 2009 Nov 12; Vol. 190 (3), pp. 333-9. - Publication Year :
- 2009
-
Abstract
- This perspective first considers the potential impact of the Viracept-EMS case in the framework of the current understanding of the low-dose effects of DNA-reactive chemicals and the approaches used to estimate health risks from genotoxins occurring as impurities in pharmaceutical products or as contaminants in the environment or workplace. It also presents an outlook on the nature of additional research building upon the Viracept-EMS case to test assumptions underlying thresholded dose-response relationships and to establish biologically based risk assessment models in lieu of default models for DNA-reactive compounds.
- Subjects :
- Alkylating Agents analysis
Animals
Dose-Response Relationship, Drug
Environmental Exposure
Ethyl Methanesulfonate analysis
Humans
Mice
Mutagenicity Tests
Mutagens analysis
No-Observed-Adverse-Effect Level
Product Surveillance, Postmarketing
Rats
Risk Assessment
Alkylating Agents toxicity
Drug Contamination
Ethyl Methanesulfonate toxicity
HIV Protease Inhibitors chemistry
Mutagens toxicity
Mutation drug effects
Nelfinavir chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3169
- Volume :
- 190
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Toxicology letters
- Publication Type :
- Academic Journal
- Accession number :
- 19866516
- Full Text :
- https://doi.org/10.1016/j.toxlet.2009.03.027