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Evaluating the potential of (188)Re-ECD/lipiodol as a therapeutic radiopharmaceutical by intratumoral injection for hepatoma treatment.
- Source :
-
Cancer biotherapy & radiopharmaceuticals [Cancer Biother Radiopharm] 2009 Oct; Vol. 24 (5), pp. 535-41. - Publication Year :
- 2009
-
Abstract
- Background/objectives: Intratumoral injection of a radiopharmaceutical is a potential modality to treat liver tumors. Rhenium-188 ((188)Re) was used to chelate with ethyl cysteinate dimer (ECD) in lipiodol solution to form (188)Re-ECD/lipiodol, which was then evaluated for its therapeutic potential in a rodent hepatoma model.<br />Materials and Methods: Male Sprague-Dawley rats were implanted with N1-S1 hepatoma cells orthotopically and randomly divided into two groups. Group 1 (n = 29) and group 2 (n = 10) received (188)Re-ECD/lipiodol (30.4 +/- 21.8 MBq/0.1 mL) and 0.1 mL of normal saline by intratumoral injection, respectively. Three rats in group 1 were imaged by micro-single-photon emission computed tomography/computed tomography scan to evaluate the biodistribution pattern. All rats were monitored for change of tumor size and survival rate after 2 months.<br />Results: The in vitro stability test showed that (188)Re-ECD was well-retained in the lipiodol phase for 48 hours. The biodistribution image revealed that radioactivity was retained well in hepatomas 24 hours postinjection. Long-term studies demonstrated that rats treated with (188)Re-ECD/Lipiodol had smaller tumor volumes and a better survival rate, compared to the control group. At the end of observation, the survival rates in groups 1 and 2 were 62% and 20%, respectively (p < 0.05).<br />Conclusions: (188)Re-ECD/lipiodol via direct intratumoral injection shows potential for treating hepatoma and warrants further clinical trials.
- Subjects :
- Animals
Cell Line, Tumor
Humans
Injections, Intralesional methods
Male
Neoplasm Transplantation
Rats
Rats, Sprague-Dawley
Treatment Outcome
Carcinoma, Hepatocellular radiotherapy
Iodized Oil therapeutic use
Liver Neoplasms radiotherapy
Radioisotopes therapeutic use
Radiopharmaceuticals therapeutic use
Rhenium therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8852
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer biotherapy & radiopharmaceuticals
- Publication Type :
- Academic Journal
- Accession number :
- 19877883
- Full Text :
- https://doi.org/10.1089/cbr.2008.0603