BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa.

Authors :: Poirel L
Docquier JD
De Luca F
Verlinde A
Ide L
Rossolini GM
Nordmann P
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2010 Jan; Vol. 54 (1), pp. 533-5. Date of Electronic Publication: 2009 Nov 02.
Publication Year :: 2010
Abstract: A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ss-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The bla(BEL-2) gene was identified from a P. aeruginosa isolate clonally related to another bla(BEL-1)-positive isolate.

Subjects :: Belgium
Cephalosporinase genetics
Cross Infection microbiology
Escherichia coli genetics
Genes, Bacterial genetics
Humans
Kinetics
Microbial Sensitivity Tests
Pseudomonas Infections microbiology
Pseudomonas aeruginosa genetics
Cephalosporinase metabolism
Cephalosporins pharmacology
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa enzymology
beta-Lactamases genetics
beta-Lactamases metabolism

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