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IL-1B-511 polymorphism is associated with increased risk of certain subtypes of gastric cancer in Chinese: a case-control study.
- Source :
-
The American journal of gastroenterology [Am J Gastroenterol] 2010 Mar; Vol. 105 (3), pp. 557-64. Date of Electronic Publication: 2009 Nov 10. - Publication Year :
- 2010
-
Abstract
- Objectives: The association of interleukin-1B (IL-1B)-511 polymorphism with gastric cancer is still controversial, and the association of IL-1B-511 polymorphism with subtypes of gastric cancer is still largely unknown. We investigated whether the association between IL-1B-511 polymorphism and gastric cancer risk varies by clinically important tumor characteristics and the prognostic value of this polymorphism in a large population-based case-control study among Chinese.<br />Methods: A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 1,010 gastric cancer patients and 1,500 healthy controls were enrolled in this study. Polymorphism in IL-1B-511 was analyzed by PCR-restriction fragment length polymorphism on 501 gastric cancers and 500 healthy controls.<br />Results: Compared with the CC genotype, carriers of IL-1B-511 TT genotype had an increased gastric cancer risk (odds ratio (OR)=1.97, 95% confidence interval (CI)=1.29-3.01, P=0.0016). TT genotype was significantly associated with intestinal type of gastric cancer (OR=3.16, 95% CI=1.74-5.71, P=0.0001) but not with diffuse or mixed-type gastric cancer. The test for OR heterogeneity between the intestinal-type and non-intestinal-type gastric cancers was statistically significant (P=0.02). In subgroup analyses, TT genotype was found to be associated with poorly differentiated gastric cancer (OR=3.31, 95% CI=1.43-3.60, P<0.0001), but not with moderately or well-differentiated gastric cancer. IL-1B-511 genotypes were not associated with the prognosis of gastric cancer patients.<br />Conclusions: IL-1B polymorphism influences certain subtypes of gastric cancer according to the clinical and pathological features. Understanding the etiologic heterogeneity of gastric cancer may result in improvements in controlling this disorder.
- Subjects :
- Adult
Aged
Case-Control Studies
Chi-Square Distribution
China epidemiology
DNA, Neoplasm genetics
Female
Genotype
Humans
Logistic Models
Male
Middle Aged
Polymorphism, Restriction Fragment Length
Prognosis
Proportional Hazards Models
Risk Factors
Stomach Neoplasms epidemiology
Interleukin-1 genetics
Polymorphism, Genetic
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1572-0241
- Volume :
- 105
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 19904240
- Full Text :
- https://doi.org/10.1038/ajg.2009.644