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Multifunctional silver-embedded magnetic nanoparticles as SERS nanoprobes and their applications.
- Source :
-
Small (Weinheim an der Bergstrasse, Germany) [Small] 2010 Jan; Vol. 6 (1), pp. 119-25. - Publication Year :
- 2010
-
Abstract
- In this study, surface-enhanced Raman spectroscopy (SERS)-encoded magnetic nanoparticles (NPs) are prepared and utilized as a multifunctional tagging material for cancer-cell targeting and separation. First, silver-embedded magnetic NPs are prepared, composed of an 18-nm magnetic core and a 16-nm-thick silica shell with silver NPs formed on the surface. After simple aromatic compounds are adsorbed on the silver-embedded magnetic NPs, they are coated with silica to provide them with chemical and physical stability. The resulting silica-encapsulated magnetic NPs (M-SERS dots) produce strong SERS signals and have magnetic properties. In a model application as a tagging material, the M-SERS dots are successfully utilized for targeting breast-cancer cells (SKBR3) and floating leukemia cells (SP2/O). The targeted cancer cells can be easily separated from the untargeted cells using an external magnetic field. The separated targeted cancer cells exhibit a Raman signal originating from the M-SERS dots. This system proves to be an efficient tool for separating targeted cells. Additionally, the magnetic-field-induced hot spots, which can provide a 1000-times-stronger SERS intensity due to aggregation of the NPs, are studied.
- Subjects :
- Macromolecular Substances chemistry
Magnetics
Materials Testing
Molecular Conformation
Particle Size
Surface Properties
Crystallization methods
Molecular Probe Techniques
Nanostructures chemistry
Nanostructures ultrastructure
Nanotechnology methods
Silver chemistry
Spectrum Analysis, Raman methods
Subjects
Details
- Language :
- English
- ISSN :
- 1613-6829
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 19904763
- Full Text :
- https://doi.org/10.1002/smll.200901459