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Aerial oxidation of hydrazines to nitrosamines.
- Source :
-
Environmental and molecular mutagenesis [Environ Mol Mutagen] 1991; Vol. 17 (1), pp. 59-62. - Publication Year :
- 1991
-
Abstract
- When 1,1-dimethylhydrazine and N-aminopiperidine were deliberately exposed to air substantial amounts of the corresponding carcinogenic nitrosamines were formed. Unoxidized samples of 1,1-dimethylhydrazine were not mutagenic while oxidized samples (which contained much higher levels of nitrosamines) were mutagenic. Both unoxidized and oxidized samples of N-aminopiperidine were mutagenic.
- Subjects :
- 1,2-Dimethylhydrazine
Animals
Biotransformation
Chromatography, Gas
Cricetinae
Dimethylhydrazines pharmacology
Male
Mesocricetus
Microsomes, Liver metabolism
Mutagenicity Tests
Oxidation-Reduction
Piperidines pharmacology
Rats
Rats, Inbred Strains
Salmonella typhimurium drug effects
Dimethylhydrazines chemistry
Hydrazines chemistry
Mutagens chemistry
Nitrosamines
Piperidines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0893-6692
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Environmental and molecular mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 1991461
- Full Text :
- https://doi.org/10.1002/em.2850170109