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Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study.
- Source :
-
Stroke [Stroke] 2010 Jan; Vol. 41 (1), pp. 173-6. Date of Electronic Publication: 2009 Nov 19. - Publication Year :
- 2010
-
Abstract
- Background and Purpose: To investigate the association between thyroid autoantibodies and moyamoya disease (MMD) in patients with an apparent euthyroid state.<br />Methods: We prospectively studied angiographically diagnosed patients with MMD. We compared demographic profiles, thyroid function test, and thyroid autoantibody status between MMD and control groups.<br />Results: A total of 63 patients with MMD, 71 patients with non-MMD stroke, and 200 healthy control subjects were included. The prevalence of elevated thyroid autoantibodies was higher in the MMD group than in other groups (P<0.01 for MMD versus non-MMD; P<0.001 for MMD versus control subjects). After adjusting for covariates, the elevated thyroid autoantibodies (OR, 4.871; 95% CI, 1.588 to 15.277) and smoking habits (OR, 0.206 for current smoker; 95% CI, 0.054 to 0.786) were independently associated with MMD versus non-MMD stroke.<br />Conclusions: Elevated thyroid autoantibodies were frequently observed in patients with MMD. The results of the present study suggest that immune aberrancies associated with or underlying thyroid autoimmunity are also playing a role in developing MMD.
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 19926842
- Full Text :
- https://doi.org/10.1161/STROKEAHA.109.562264