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Molecular characteristics of occult hepatitis B virus from blood donors in southeast China.
- Source :
-
Journal of clinical microbiology [J Clin Microbiol] 2010 Feb; Vol. 48 (2), pp. 357-62. Date of Electronic Publication: 2009 Nov 25. - Publication Year :
- 2010
-
Abstract
- The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg(+)) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg(+) donors, carriers with OBIs versus HBsAg(+) asymptomatic carriers, and carriers with OBIs versus HBsAg(+) chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections.
- Subjects :
- Adult
Amino Acid Sequence
Amino Acid Substitution
China
DNA, Viral genetics
Female
Genotype
Hepatitis B Surface Antigens genetics
Hepatitis B, Chronic virology
Humans
Male
Molecular Sequence Data
Mutation, Missense
Sequence Analysis, DNA
Young Adult
Blood Donors
Carrier State virology
Hepatitis B virology
Hepatitis B virus genetics
Hepatitis B virus isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1098-660X
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 19940057
- Full Text :
- https://doi.org/10.1128/JCM.01781-09