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[Hereditary iron overload].
- Source :
-
Pathologie-biologie [Pathol Biol (Paris)] 2010 Oct; Vol. 58 (5), pp. 316-23. Date of Electronic Publication: 2009 Nov 25. - Publication Year :
- 2010
-
Abstract
- The field of hereditary iron overload has known, in the recent period, deep changes mainly related to major advances in molecular biology. It encompasses now a series of genetic entities. The mechanistic understanding of iron overload development and iron toxicity has greatly improved. The diagnostic approach has become essentially noninvasive with a major role for biological tests. From the therapeutic viewpoint, the phlebotomy treatment is now enriched by the possibility of resorting to oral chelation and by innovative perspectives directly linked to our improvement in the molecular understanding of these diseases.<br /> (Copyright © 2009 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Antimicrobial Cationic Peptides deficiency
Antimicrobial Cationic Peptides genetics
Cation Transport Proteins deficiency
Cation Transport Proteins genetics
Ceruloplasmin deficiency
Ceruloplasmin genetics
Chelation Therapy
Forecasting
Genetic Counseling
Hemochromatosis classification
Hemochromatosis diagnosis
Hemochromatosis drug therapy
Hemochromatosis genetics
Hemochromatosis therapy
Hemochromatosis Protein
Hemosiderosis genetics
Hemosiderosis metabolism
Hepcidins
Histocompatibility Antigens Class I genetics
Humans
Iron metabolism
Iron Metabolism Disorders genetics
Iron Overload diagnosis
Iron Overload drug therapy
Iron Overload physiopathology
Iron Overload therapy
Liver metabolism
Membrane Proteins deficiency
Membrane Proteins genetics
Molecular Diagnostic Techniques
Neurodegenerative Diseases genetics
Phlebotomy
Iron Overload genetics
Subjects
Details
- Language :
- French
- ISSN :
- 1768-3114
- Volume :
- 58
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pathologie-biologie
- Publication Type :
- Academic Journal
- Accession number :
- 19942367
- Full Text :
- https://doi.org/10.1016/j.patbio.2009.10.011