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[Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with diabetic autonomic neuropathy].
- Source :
-
Likars'ka sprava [Lik Sprava] 2009 Jan-Feb (1-2), pp. 22-8. - Publication Year :
- 2009
-
Abstract
- The authors have studied structural functional peculiarities of the left ventricle in patients with type 2 diabetes mellitus, dependent on the presence of cardiovascular form of diabetic autonomic neuropathy and dynamics of the studied parameters in patients with type 2 diabetes mellitus complicated with cardiovascular form of diabetic autonomic neuropathy treated with alpha-lipoic acid. The study included 82 patients with type 2 diabetes mellitus. The study has shown that the development of cardiovascular form of diabetic autonomic neuropathy results in dilatation and hypertrophy of the left ventricle walls, increase of its weight and impairment of diastolic function of the left ventricle manifesting itself by a decrease of early filling phase and an increase of myocardial hardness, as well as a decrease of cardiac rhythm variability and increase of QT-interval. Use of alpha-lipoic acid in complex treatment of diabetic autonomic neuropathy contributes to more effective influencing on diastolic function of the left ventricle and electrophysiological properties of the myocardium.
- Subjects :
- Diabetes Mellitus, Type 2 diagnostic imaging
Diabetes Mellitus, Type 2 drug therapy
Diabetic Neuropathies diagnostic imaging
Diabetic Neuropathies drug therapy
Drug Therapy, Combination
Echocardiography, Doppler
Heart Ventricles diagnostic imaging
Heart Ventricles drug effects
Heart Ventricles innervation
Humans
Hypoglycemic Agents administration & dosage
Middle Aged
Thioctic Acid administration & dosage
Treatment Outcome
Ventricular Function, Left physiology
Diabetes Mellitus, Type 2 physiopathology
Diabetic Neuropathies physiopathology
Heart Ventricles physiopathology
Hypoglycemic Agents therapeutic use
Thioctic Acid therapeutic use
Ventricular Function, Left drug effects
Subjects
Details
- Language :
- Russian
- ISSN :
- 1019-5297
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Likars'ka sprava
- Publication Type :
- Academic Journal
- Accession number :
- 19953987